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Fos Transcription Factor Activity Assay

SKU:
TFAB00077
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
Fos
Reactivity:
Human
Mouse
Rat
€599
Frequently bought together:

Description

system_update_altDatasheet

Fos Transcription Factor Activity Assay

The FOS Transcription Factor Activity Assay kit is a reliable tool for quantifying the activity of the FOS transcription factor in cell lysates. This kit offers high sensitivity and specificity, allowing for accurate and reproducible results in a variety of research applications.The FOS transcription factor plays a key role in regulating gene expression and is involved in numerous cellular processes, including cell growth, differentiation, and response to external stimuli. Dysregulation of FOS activity has been implicated in various diseases, including cancer, inflammatory disorders, and neurological conditions, highlighting its importance as a potential therapeutic target.

By using the FOS Transcription Factor Activity Assay kit, researchers can gain valuable insights into the role of FOS in disease pathology and identify potential pathways for intervention. With its user-friendly format and robust performance, this kit is an essential tool for advancing research in the field of transcriptional regulation.

Product Name:Fos Transcription Factor Activity Assay
Product Code:TFAB00077
Target:Fos
Synonyms:Cellular oncogene fos, G0/G1 switch regulatory protein 7
Reactivity:Human, Mouse, Rat
Sample Types:Nuclear or cell lysates

The Assay Genie Fos transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:Fos: a proto-oncogenic transcription factor of the bZIP family. Dimerizes with proteins of the JUN family, thereby forming the transcription factor complex AP-1. FOS proteins function as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of FOS has also been associated with apoptotic cell death. Expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; DNA-binding; Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: nucleoplasm; transcription factor complex; neuron projection; membrane; endoplasmic reticulum; nucleus; cytosol

Molecular Function:protein binding; double-stranded DNA binding; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; response to gravity; response to cAMP; positive regulation of osteoclast differentiation; positive regulation of transcription, DNA-dependent; response to toxin; stress-activated MAPK cascade; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; female pregnancy; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of transcription factor activity; transforming growth factor beta receptor signaling pathway; conditioned taste aversion; DNA methylation; inflammatory response; toll-like receptor 4 signaling pathway; aging; response to corticosterone stimulus; response to drug; response to light stimulus; nervous system development; MyD88-independent toll-like receptor signaling pathway; sleep; toll-like receptor 2 signaling pathway; cellular response to hormone stimulus; regulation of transcription from RNA polymerase II promoter; MyD88-dependent toll-like receptor signaling pathway; response to mechanical stimulus; response to cytokine stimulus; cellular response to extracellular stimulus; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; response to cold; toll-like receptor 9 signaling pathway; response to progesterone stimulus

NCBI Summary:The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
UniProt Code:P01100
NCBI GenInfo Identifier:120470
NCBI Gene ID:2353
NCBI Accession:P01100.1
UniProt Secondary Accession:P01100,P18849, A8K4E2, B4DQ65,
UniProt Related Accession:P01100
Molecular Weight:380
NCBI Full Name:Proto-oncogene c-Fos
NCBI Synonym Full Names:FBJ murine osteosarcoma viral oncogene homolog
NCBI Official Symbol:FOS  
NCBI Official Synonym Symbols:p55; AP-1; C-FOS  
NCBI Protein Information:proto-oncogene c-Fos; activator protein 1; cellular oncogene c-fos; G0/G1 switch regulatory protein 7; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)
UniProt Protein Name:Proto-oncogene c-Fos
UniProt Synonym Protein Names:Cellular oncogene fos; G0/G1 switch regulatory protein 7
Protein Family:Fos-related antigen
UniProt Gene Name:FOS  
UniProt Entry Name:FOS_HUMAN
AntibodiesELISA Kits
Anti-c-Fos Antibody (CAB0236)FOS (Phospho-Ser32) Colorimetric Cell-Based ELISA Kit
Anti-c-Fos Antibody (CAB16641)FOS (Phospho-Thr232) Colorimetric Cell-Based ELISA Kit
Anti-FOS Antibody (CAB17351)
Anti-c-Fos Antibody (CAB2444)
Anti-Phospho-FOS-T232 Antibody (CABP0038)

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