The FOS Polyclonal Antibody (CAB0236) is a valuable tool for research involving FOS, a key transcription factor involved in cell proliferation, differentiation, and transformation. This antibody, produced in rabbits, exhibits high specificity towards human samples and has been validated for use in Western blotting applications. By binding specifically to the FOS protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in molecular biology, oncology, and developmental biology.FOS is a crucial regulator of gene expression, playing a central role in cellular processes such as growth, survival, and response to external stimuli.
Dysregulation of FOS has been implicated in various diseases, including cancer, inflammatory disorders, and neurological conditions. Therefore, understanding the function and regulation of FOS is essential for developing targeted therapies and diagnostic tools for these diseases.Overall, the FOS Polyclonal Antibody (CAB0236) provides researchers with a reliable tool for investigating the intricate roles of FOS in cellular signaling pathways and disease processes. Its high specificity and sensitivity make it a valuable asset for studies aiming to uncover the molecular mechanisms underlying various physiological and pathological conditions.
Product Name:
c-Fos Rabbit Polyclonal Antibody
SKU:
CAB0236
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human c-Fos (NP_005243.1).
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.
Purification Method:
Affinity purification
Gene ID:
2353
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using c-Fos Rabbit pAb (CAB0236) at 1:1000 dilution.HeLa cells were treated by PMA/TPA (200 nM) at 37℃ for 15 minutes after serum-starvation overnight.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
