The Formyl Histone H2B (K108) Monoclonal Antibody is a highly specific antibody designed for research involving the histone H2B protein modification at lysine 108. This modification plays a key role in gene regulation, chromatin structure, and DNA repair processes.The antibody, generated using hybridoma technology, is highly sensitive and specific for detecting the histone H2B K108 modification in various cell types and tissues. It is validated for use in immunofluorescence, immunoprecipitation, and chromatin immunoprecipitation (ChIP) assays, making it a versatile tool for epigenetics and chromatin research.Histone modifications, such as the formyl histone H2B K108, have been linked to various diseases, including cancer and developmental disorders.
Understanding the role of this specific modification in gene regulation and chromatin dynamics is essential for uncovering new therapeutic targets and developing novel treatment strategies.Researchers studying epigenetics, chromatin biology, and gene regulation will benefit from the high quality and specificity of the Formyl Histone H2B (K108) Monoclonal Antibody in their experiments. It provides reliable and accurate results, enabling detailed analysis of the histone H2B K108 modification and its impact on cellular processes.
Product Name:
Formyl-Histone H2B-K108 Monoclonal Antibody
SKU:
CAB0032
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat,Other (Wide Range Predicted)
Immunogen:
A synthesized peptide derived from human Histone H2B (formyl K108).
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity.
Purification Method:
Affinity purification
Gene ID:
3017/8349
Clone Number:
ARC2492
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human liver using Formyl-Histone H2B-K108 Rabbit mAb (CAB0032) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
