The FOLR1 Polyclonal Antibody (CAB15672) is a valuable tool for researchers studying FOLR1, also known as folate receptor alpha. This cell surface protein is involved in the transport of folate into cells, playing a crucial role in cell growth and division. The antibody, generated in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications.By binding specifically to the FOLR1 protein, this antibody enables the detection and analysis of FOLR1 expression in a variety of cell types. Its versatility and reliability make it well-suited for studies in cancer research, as FOLR1 is often overexpressed in cancer cells and has been implicated in tumor growth and progression.
Understanding the role of FOLR1 in cancer development and progression is essential for the development of targeted therapies that exploit the unique properties of this receptor. By utilizing the FOLR1 Polyclonal Antibody, researchers can further investigate the molecular mechanisms underlying FOLR1 function and its potential as a therapeutic target in cancer treatment.
Product Name:
FOLR1 Rabbit Polyclonal Antibody
SKU:
CAB15672
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Folate Binding Protein(FBP) / FOLR1 (NP_000793.1).
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2348
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat brain, using Folate Binding Protein(FBP) / FOLR1 Rabbit pAb (CAB15672) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
