The Folliculin Polyclonal Antibody (CAB6493) is a valuable tool for researchers studying folliculin, a tumor suppressor protein implicated in multiple cellular pathways. This polyclonal antibody, generated in rabbits, is highly specific for human samples and is validated for use in various applications, including Western blotting and immunohistochemistry.Folliculin is known to interact with multiple proteins involved in cell growth, proliferation, and metabolism, making it a key player in cellular homeostasis and tumor suppression.
Research into folliculin's role in diseases like Birt-Hogg-Dube syndrome and cancer has highlighted its potential as a therapeutic target for these conditions.By using the Folliculin Polyclonal Antibody (CAB6493), researchers can accurately detect and analyze folliculin expression in different cell types and tissues, providing valuable insights into the protein's function and its implications in various diseases. This antibody is a valuable asset for studies in cancer biology, genetics, and cell signaling pathways.
Product Name:
FLCN Rabbit Polyclonal Antibody
SKU:
CAB6493
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 341-579 of human FLCN (NP_659434.2).
This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
201163
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FLCN antibody (CAB6493) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
