The FOLH1 Polyclonal Antibody (CAB17485) is a valuable tool for researchers studying FOLH1, a key protein involved in various biological processes, including cell growth and metabolism. This antibody, generated in rabbits, demonstrates high reactivity to human samples and is optimized for Western blot applications. By binding specifically to the FOLH1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for investigations in the fields of biochemistry and oncology.
FOLH1, also known as prostate-specific membrane antigen (PSMA), is a promising target for cancer therapy and imaging due to its elevated expression in prostate cancer cells. Its role in promoting tumor growth and angiogenesis makes it a focal point in cancer research, with potential applications in diagnosis and treatment. Understanding the function and regulation of FOLH1 is crucial for the development of targeted therapies and diagnostic tools that can improve patient outcomes in prostate cancer and other FOLH1-related conditions.
Product Name:
PSMA/FOLH1 Polyclonal Antibody
SKU:
CAB17485
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PSMA/FOLH1 (NP_004467.1).
Cell membrane, Cytoplasm, Single-pass type II membrane protein.
Calculated MW:
84kDa
Observed MW:
105kDa
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
Purification Method:
Affinity purification
Gene ID:
2346
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PSMA/FOLH1 antibody (CAB17485) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
