The FN1 Polyclonal Antibody (CAB16678) is a valuable tool for research involving fibronectin (FN1), a glycoprotein found in the extracellular matrix and implicated in cell adhesion, growth, migration, and differentiation. The antibody, produced in rabbits, is highly specific to human FN1 and is validated for use in applications such as immunohistochemistry and ELISA.Fibronectin is a key player in various cellular processes, including wound healing, embryonic development, and tissue remodeling. Dysregulation of FN1 expression has been linked to a range of diseases, including cancer, fibrosis, and cardiovascular disorders.
Studying the role of FN1 in these conditions is essential for developing targeted therapies and biomarkers for diagnosis and prognosis.The FN1 Polyclonal Antibody binds specifically to the FN1 protein, allowing for accurate detection and quantification in tissue samples and cell culture models. Its high specificity and sensitivity make it an ideal tool for researchers in fields such as cell biology, pathology, and drug discovery, looking to unravel the complex mechanisms involving fibronectin in health and disease.
Product Name:
Fibronectin Rabbit Polyclonal Antibody
SKU:
CAB16678
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2205-2477 of human Fibronectin (NP_997647.2).
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
2335
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Fibronectin Rabbit pAb (CAB16678) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
