The FMRP Rabbit Monoclonal Antibody (CAB4539) is a valuable tool for researchers studying Fragile X mental retardation protein (FMRP), a key player in neurodevelopment and synaptic plasticity. This antibody, generated using rabbit monoclonal technology, is highly specific and sensitive for detecting FMRP in human samples.FMRP is known to play a crucial role in RNA metabolism and translation regulation, making it essential for proper brain function and neuronal development. Dysregulation of FMRP has been linked to neurodevelopmental disorders such as Fragile X syndrome, autism, and intellectual disabilities.
This monoclonal antibody is validated for use in Western blot applications, allowing for accurate detection and analysis of FMRP levels in various cell types and tissues. Its high affinity binding to FMRP provides researchers with a reliable tool for investigating FMRP's function and potential therapeutic targets in neurological disorders.By utilizing the FMRP Rabbit Monoclonal Antibody (CAB4539), researchers can gain insights into the molecular mechanisms underlying neurodevelopmental disorders and potentially identify new strategies for diagnosis and treatment.
Product Name:
FMRP Rabbit Monoclonal Antibody
SKU:
CAB4539
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FMRP (Q06787).
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
2332
Clone Number:
ARC1026
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using FMRP Rabbit mAb (CAB4539) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
