The FMR1 Polyclonal Antibody (CAB6092) is a valuable research tool for studying Fragile X Mental Retardation 1 (FMR1), a gene associated with neurodevelopmental disorders. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it suitable for use in Western blot applications.FMR1 is important for brain development and functioning, and mutations in this gene are linked to Fragile X syndrome, the most common inherited form of intellectual disability. The FMR1 Polyclonal Antibody binds specifically to the FMR1 protein, enabling accurate detection and analysis in various cell types.
Research on FMR1 is essential for understanding the underlying mechanisms of Fragile X syndrome and other neurodevelopmental conditions. By studying the function of the FMR1 gene and its protein product, researchers can gain insights into potential therapeutic targets and interventions for these disorders. The FMR1 Polyclonal Antibody is a valuable tool for scientists and clinicians working in the field of neurobiology and genetic disorders.
Product Name:
FMRP Rabbit Polyclonal Antibody
SKU:
CAB6092
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human FMRP (NP_002015.1).
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
2332
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using FMRP Rabbit pAb (CAB6092) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
