The FMR1 Polyclonal Antibody (CAB5645) is a valuable tool for researchers studying Fragile X mental retardation syndrome, a genetic disorder caused by the absence of the FMR1 gene product. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in various applications, including Western blot analysis.The FMR1 antibody specifically targets the FMR1 protein, enabling precise detection and analysis in a range of cell types. By studying the expression and function of FMR1, researchers can gain insights into the molecular mechanisms underlying Fragile X syndrome, a leading cause of inherited intellectual disability and autism spectrum disorders.
The role of the FMR1 protein in neural development and synaptic function highlights its significance in neurobiological research. By investigating the impact of FMR1 mutations on brain function, researchers can uncover potential therapeutic targets for treating Fragile X syndrome and related conditions. The FMR1 Polyclonal Antibody is a valuable tool for advancing our understanding of this complex disorder and developing targeted interventions.
Product Name:
FMRP Rabbit Polyclonal Antibody
SKU:
CAB5645
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human FMRP (NP_001172011.1).
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
2332
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using FMRP Rabbit pAb (CAB5645) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 50s.
