FMRP Rabbit Polyclonal Antibody (CAB5645)
- SKU:
- CAB5645
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | FMRP Rabbit Polyclonal Antibody |
SKU: | CAB5645 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human FMRP (NP_001172011.1). |
Sequence: | MEEL VVEV RGSN GAFY KAFV KDVH EDSI TVAF ENNW QPDR QIPF HDVR FPPP VGYN KDIN ESDE VEVY SRAN EKEP CCWW LAKV RMIK GEFY VIEY AACD ATYN EIVT IERL RSVN PNKP ATKD TFHK IKLD VPED LRQM CAKE AAHK DFKK AVGA FSVT YDPE NYQL VILS INEV TSKR AHML IDMH FRSL RTKL SLIM RNEE ASKQ LESS RQLA SRFH EQFI VRED LMGL AIGT HGAN IQQA RKVP GVTA IDLD EDTC TFHI YGED QDAV KKAR SFLE FAED VIQV PR |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | POF; FMRP; POF1; FRAXA |
Positive Sample: | MCF7,OVCAR3,SW480,THP-1,Jurkat,SH-SY5Y,Mouse kidney,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, nucleolus. |
Calculated MW: | 71kDa |
Observed MW: | 85kDa |
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 2332 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |