The Fibromodulin Polyclonal Antibody (CAB6375) is a valuable tool for researchers studying fibromodulin, a protein involved in extracellular matrix organization and regulation. This antibody, raised in rabbits, is highly specific to human fibromodulin and has been validated for use in various applications, including Western blot and immunohistochemistry.Fibromodulin is known for its role in collagen fibrillogenesis and tissue repair, making it a key player in processes such as wound healing and tissue remodeling. Dysregulation of fibromodulin expression has been implicated in various diseases, such as osteoarthritis and fibrosis, highlighting its importance in maintaining tissue integrity and function.
By using the Fibromodulin Polyclonal Antibody, researchers can accurately detect and analyze fibromodulin levels in different cell types and tissues, providing valuable insights into its biological functions and potential therapeutic targets. This antibody is a valuable tool for studies in the fields of musculoskeletal biology, tissue engineering, and regenerative medicine.
Product Name:
FMOD Rabbit Polyclonal Antibody
SKU:
CAB6375
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-376 of human FMOD (NP_002014.2).
Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2331
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FMOD antibody (CAB6375) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
