The FMO4 Polyclonal Antibody (PACO26801) is a valuable tool for researchers studying FMO4, a member of the flavin-containing monooxygenase family involved in drug metabolism and xenobiotic detoxification. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds specifically to the FMO4 protein, allowing for precise detection and analysis in various cell types.FMO4, also known as Flavin-containing monooxygenase 4, is essential for the metabolism of various drugs and environmental toxins, making it a target of interest in pharmacology and toxicology research.
Understanding the role of FMO4 in drug metabolism pathways and detoxification processes is crucial for developing new drugs and improving drug safety.Overall, the FMO4 Polyclonal Antibody is a valuable tool for researchers studying drug metabolism, xenobiotic detoxification, and related pathways. Its specificity and reliability make it ideal for research in pharmacology, toxicology, and drug development.
FMO4: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Belongs to the FMO family.Protein type: Membrane protein, integral; EC 1.14.13.8; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450Chromosomal Location of Human Ortholog: 1q24.3Cellular Component: endoplasmic reticulum membrane; integral to membraneMolecular Function: FAD binding; NADP binding; flavin-containing monooxygenase activityBiological Process: drug catabolic process
UniProt Protein Details:
NCBI Summary:
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Sep 2013]
