The FMNL3 Antibody (PAC046786) is a powerful tool for researchers studying FMNL3, a formin-like cytoskeleton regulator involved in cell migration and invasion. This polyclonal antibody, produced in rabbits, exhibits high specificity for human samples and is validated for use in Western blotting applications. By binding specifically to the FMNL3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an invaluable asset for studies in cell biology and cancer research.FMNL3, a member of the formin family of proteins, plays a crucial role in actin cytoskeleton dynamics and cell motility.
Its implications in cell migration and invasion processes make it a key player in cancer progression and metastasis. Research on FMNL3 is vital for understanding the mechanisms underlying tumor invasion and developing targeted therapies to combat cancer spread.By utilizing the FMNL3 Antibody (PAC046786), researchers can gain valuable insights into the function and regulation of FMNL3 in physiological and pathological conditions. This antibody opens up new possibilities for investigating the role of FMNL3 in cancer biology and potentially identifying novel therapeutic strategies for combating invasive cancers.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO46786 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO46786 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human testis tissue using PACO46786 at dilution of 1:100.
Background:
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.
Synonyms:
Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3), FMNL3, FHOD3 FRL2 KIAA2014 WBP3
UniProt Protein Function:
FMNL3: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Belongs to the formin homology family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 12q13.12Cellular Component: cytoplasmMolecular Function: Rho GTPase binding; GTPase activating protein binding; actin bindingBiological Process: regulation of cell shape; cell migration; cytoskeleton organization and biogenesis; actin cytoskeleton organization and biogenesis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
