The FMN2 Antibody (PAC019671) is a crucial tool for researchers studying FMN2, a protein that plays a key role in various cellular processes, including cell division and migration. This polyclonal antibody, generated in rabbits, is highly specific to human samples and has been validated for Western blot applications. By binding to the FMN2 protein, this antibody allows for the detection and analysis of FMN2 expression in different cell types, making it an essential tool for studies in cell biology and cancer research.
FMN2, also known as formin 2, is involved in the organization of the cytoskeleton and is essential for proper cell division and migration. Dysregulation of FMN2 has been linked to cancer progression and metastasis, making it a promising target for the development of cancer therapies. By understanding the function of FMN2, researchers can uncover new insights into cancer biology and potentially identify novel therapeutic targets for the treatment of cancer.
Antibody Name:
FMN2 Antibody (PACO19671)
Antibody SKU:
PACO19671
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human FMN2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19671(FMN2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19671(FMN2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Formin homology (FH) domain proteins (see FMN1; MIM 136535) play a role in cytoskeletal organization and/or establishment of cell polarity.
Synonyms:
formin 2
UniProt Protein Function:
FMN2: Belongs to the formin homology family. Cappuccino subfamilyProtein type: Nucleolus; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 1q43Cellular Component: endoplasmic reticulum membrane; cytoplasmic vesicle membrane; microvillus; perinuclear region of cytoplasm; plasma membrane; nucleolus; spindle; cell cortex; cytosol; actin cytoskeletonMolecular Function: actin bindingBiological Process: oogenesis; vesicle-mediated transport; homologous chromosome movement towards spindle pole during meiosis I; establishment of meiotic spindle localization; protein transport; intracellular transport; multicellular organismal development; polar body extrusion after meiotic divisions; negative regulation of protein catabolic process; response to DNA damage stimulus; negative regulation of apoptosisDisease: Mental Retardation, Autosomal Recessive 47
UniProt Protein Details:
NCBI Summary:
Formin homology (FH) domain proteins (see FMN1; MIM 136535) play a role in cytoskeletal organization and/or establishment of cell polarity.[supplied by OMIM, Apr 2010]
