The FLVCR2 Polyclonal Antibody (CAB7815) is a powerful tool for researchers studying FLVCR2, a key protein involved in cellular iron homeostasis and heme transport. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By specifically binding to the FLVCR2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for investigations in the fields of biochemistry and molecular biology.
FLVCR2, also known as the cellular iron exporter, plays a crucial role in regulating intracellular iron levels and maintaining overall iron balance in the body. Dysregulation of FLVCR2 has been linked to various diseases such as anemia, neurodegenerative disorders, and cancer. Understanding the functions and mechanisms of FLVCR2 can provide valuable insights into these pathological conditions and may lead to the development of novel therapeutic strategies targeting iron metabolism disorders.
Product Name:
FLVCR2 Rabbit Polyclonal Antibody
SKU:
CAB7815
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human FLVCR2 (NP_060261.2).
This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
55640
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FLVCR2 antibody (CAB7815) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
