The FLVCR1 Polyclonal Antibody (CAB15153) is a valuable tool for researchers studying FLVCR1, a critical cell surface protein involved in heme transport and iron homeostasis. This antibody, raised in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the FLVCR1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in cell biology, hematology, and iron metabolism.FLVCR1 plays a crucial role in maintaining cellular iron balance by facilitating the export of heme, the iron-containing molecule essential for various cellular processes.
Dysregulation of FLVCR1 has been implicated in diseases such as anemia, porphyria, and even cancer, highlighting its importance in human health and disease. Research on FLVCR1 can provide valuable insights into the mechanisms underlying these conditions and may lead to the development of novel therapeutic strategies targeting heme transport and iron metabolism.Overall, the FLVCR1 Polyclonal Antibody is a reliable tool for investigating the function and regulation of FLVCR1 in various biological contexts, offering researchers the opportunity to deepen their understanding of iron homeostasis and its implications for human health.
Product Name:
FLVCR1 Rabbit Polyclonal Antibody
SKU:
CAB15153
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human FLVCR1 (NP_054772.1).
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome.
Purification Method:
Affinity purification
Gene ID:
28982
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Raji cells, using FLVCR1 Rabbit pAb (CAB15153) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
