FLT3LG Antibody (PACO21788)
- SKU:
- PACO21788
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
FLT3LG Antibody (PACO21788)
The FLT3LG Polyclonal Antibody (PAC021788) is a crucial tool for researchers studying the FLT3 ligand (FLT3LG) protein, which plays a vital role in hematopoiesis and immune regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the FLT3LG protein, it enables researchers to detect and analyze FLT3LG expression in a variety of cell types, making it ideal for studies in immunology, oncology, and hematology.
FLT3LG is known for its role in regulating the development and differentiation of hematopoietic stem cells, as well as promoting the expansion and activation of dendritic cells. Its involvement in immune cell development and function makes it a key target for research into diseases such as leukemia, lymphoma, and autoimmune disorders. Understanding the mechanisms by which FLT3LG operates is essential for developing targeted therapies that can modulate immune responses and hematopoiesis in disease settings.
| Antibody Name: | FLT3LG Antibody (PACO21788) |
| Antibody SKU: | PACO21788 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human Flt3 ligand. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Savvides S.N., Nat. Struct. Biol. 7:486-491(2000). |
| Clonality: | Polyclonal |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from Jurkat cells, using Flt3 ligand antibody. |
| Synonyms: | SL cytokine [Precursor]; Fms-related tyrosine kinase 3 ligand; Flt3 ligand; Flt3L; FLT3LG |
| UniProt Protein Function: | FLT3LG: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine; Ligand, receptor tyrosine kinase; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: extracellular space; membrane; integral to membrane Molecular Function:protein homodimerization activity; cytokine activity; receptor tyrosine kinase binding; receptor binding Biological Process: regulation of myeloid dendritic cell activation; positive regulation of natural killer cell differentiation; lymphocyte differentiation; embryonic hemopoiesis; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; signal transduction; positive regulation of myoblast differentiation |
| NCBI Summary: | Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011] |
| UniProt Code: | P49771 |
| NCBI GenInfo Identifier: | 1706818 |
| NCBI Gene ID: | 2323 |
| NCBI Accession: | P49771.1 |
| UniProt Secondary Accession: | P49771,Q05C96, A0AVC2, B9EGH2, |
| UniProt Related Accession: | P49771 |
| Molecular Weight: | approximately 150 kDa |
| NCBI Full Name: | Fms-related tyrosine kinase 3 ligand |
| NCBI Synonym Full Names: | fms-related tyrosine kinase 3 ligand |
| NCBI Official Symbol: | FLT3LGÂ Â |
| NCBI Official Synonym Symbols: | FL; FLT3LÂ Â |
| NCBI Protein Information: | fms-related tyrosine kinase 3 ligand; flt3 ligand |
| UniProt Protein Name: | Fms-related tyrosine kinase 3 ligand |
| UniProt Synonym Protein Names: | SL cytokine |
| Protein Family: | Receptor-type tyrosine-protein kinase |
| UniProt Gene Name: | FLT3LGÂ Â |
| UniProt Entry Name: | FLT3L_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
FLT3LG Antibody (PACO26793)
FLT3LG Antibody (PACO02184)
FLT3LG Antibody (PACO00811)
Anti-FLT3LG Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0265)
