The FLT1 Polyclonal Antibody (CAB1277) is a vital tool for researchers studying the FLT1 protein, a cell surface receptor involved in angiogenesis and vascular development. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been rigorously validated for Western blot applications.FLT1, also known as vascular endothelial growth factor receptor 1 (VEGFR-1), plays a crucial role in regulating blood vessel formation and growth. By binding to FLT1, this antibody allows for the detection and analysis of FLT1 expression in various cell types, enabling researchers to investigate its involvement in processes such as tumor angiogenesis, cardiovascular development, and wound healing.
Given FLT1's significance in angiogenesis and vascular biology, this polyclonal antibody is an invaluable tool for researchers exploring novel therapeutic strategies for conditions such as cancer, ischemic diseases, and retinopathy. Understanding the mechanisms underlying FLT1 signaling is essential for the development of targeted therapies aimed at modulating angiogenic processes for clinical benefit.
Product Name:
VEGFR1 Rabbit Polyclonal Antibody
SKU:
CAB1277
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human VEGFR1 (NP_002010.2).
Cell membrane, Cytoplasm, Endosome, Secreted, Single-pass type I membrane protein.
Calculated MW:
151kDa
Observed MW:
151kDa
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
Purification Method:
Affinity purification
Gene ID:
2321
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using VEGFR1 Rabbit pAb (CAB1277) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
