The FLRT1 Polyclonal Antibody (PAC040690) is a valuable tool for researchers studying FLRT1, a cell surface protein known to play a role in neural development and axon guidance. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the FLRT1 protein, this antibody allows for the detection and analysis of FLRT1 expression in a variety of cell types, making it an essential component for studies in neuroscience and developmental biology.
FLRT1, also known as Fibronectin leucine-rich transmembrane protein 1, is essential for proper brain development and is involved in axonal pathfinding during neuronal development. Its role in mediating cell-cell interactions and regulating signaling pathways makes it a promising target for research into neurological disorders and brain development. Understanding the function and expression of FLRT1 is critical for advancing our knowledge of neurodevelopmental processes and identifying potential therapeutic targets for neurological diseases.
Western blot. All lanes: FLRT1 antibody at 2µg/ml. Lane 1: Mouse kidney tissue. Lane 2: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 72 kDa. Observed band size: 72 kDa.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO40690 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO40690 at dilution of 1:100.
Background:
May have a function in cell adhesion and/or receptor signaling.
Synonyms:
Leucine-rich repeat transmembrane protein FLRT1 (Fibronectin-like domain-containing leucine-rich transmembrane protein 1), FLRT1
UniProt Protein Function:
FLRT1: May have a function in cell adhesion and/or receptor signaling.Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integralChromosomal Location of Human Ortholog: 11q13.1Cellular Component: cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; endoplasmic reticulum membrane; extracellular space; focal adhesion; integral to plasma membrane; intercellular junction; perinuclear region of cytoplasm; proteinaceous extracellular matrixMolecular Function: fibroblast growth factor receptor binding; protein binding, bridging; protein kinase inhibitor activity; receptor signaling protein activityBiological Process: cell adhesion; cytokine and chemokine mediated signaling pathway; dendrite development; fibroblast growth factor receptor signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; positive regulation of synaptogenesis
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]
