The FLNC Polyclonal Antibody (CAB13018) is a high-quality research tool designed for the study of Filamin C (FLNC), a protein involved in cell structure and function. This antibody is raised in rabbits and has been validated for use in various applications, including Western blot and immunohistochemistry.FLNC is a key regulator of cytoskeletal dynamics and cell motility, playing important roles in muscle development, cardiovascular function, and cell signaling pathways. Dysregulation of FLNC has been implicated in various diseases, including myopathies, cardiomyopathies, and cancer.
By specifically binding to FLNC, this antibody enables researchers to detect and analyze the protein in different cell types and tissues, providing valuable insights into its function and potential therapeutic implications. Whether studying normal cellular processes or disease mechanisms, the FLNC Polyclonal Antibody is a valuable tool for advancing research in cell biology, physiology, and pathology.
Product Name:
FLNC Rabbit Polyclonal Antibody
SKU:
CAB13018
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2160-2340 of human FLNC (NP_001449.3).
Cytoplasm, Membrane, Peripheral membrane protein, Z line, cytoskeleton, myofibril, sarcomere.
Calculated MW:
291kDa
Observed MW:
302kDa
This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Mutations in this gene are a cause of cardiopathy. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2318
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FLNC Rabbit pAb (CAB13018) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
