The FLNA Polyclonal Antibody (CAB0927) is a crucial tool for researchers studying Filamin A (FLNA), a widely expressed actin-binding protein essential for cell structure and function. This antibody, produced in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blot applications. By specifically binding to FLNA, researchers can accurately detect and analyze its expression in various cell types, making it an invaluable resource for studies in cell biology, developmental biology, and cancer research.Filamin A plays a pivotal role in cell adhesion, migration, and signaling pathways, making it a key player in processes such as cytoskeleton remodeling and cell motility.
Dysregulation of FLNA has been linked to a range of diseases, including developmental disorders, cancer, and cardiovascular diseases, highlighting the importance of understanding its function and regulation. By utilizing the FLNA Polyclonal Antibody, researchers can gain valuable insights into the molecular mechanisms underlying these diseases, paving the way for the development of novel therapeutic strategies targeting FLNA.
Product Name:
Filamin A Rabbit Polyclonal Antibody
SKU:
CAB0927
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2348-2647 of human Filamin A (NP_001104026.1).
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2316
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Filamin A Rabbit pAb (CAB0927) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
