The FLII Polyclonal Antibody (Paco41958) is a versatile tool for researchers studying FLII, a protein involved in various cellular processes such as cell migration, cytoskeletal organization, and gene transcription. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot assays. By targeting the FLII protein, this antibody enables accurate detection and analysis in different cell types, making it ideal for investigations in cell biology, cancer research, and developmental biology.FLII, also known as Flightless-I homolog, plays a crucial role in regulating actin dynamics and signal transduction pathways that control cell movement and gene expression.
Its diverse functions make it a valuable target for research into diseases such as cancer, neurodevelopmental disorders, and cardiovascular diseases. By understanding the molecular mechanisms of FLII, researchers can develop targeted therapies to intervene in cellular processes associated with these diseases.Overall, the FLII Polyclonal Antibody (Paco41958) is a valuable tool for researchers interested in unraveling the complexities of FLII biology and its implications for human health and disease.
Antibody Name:
Flii Antibody (PACO41958)
Antibody SKU:
PACO41958
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse Protein flightless-1 homolog protein (495-827AA)
May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling By similarity. Essential for early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.
Synonyms:
Protein flightless-1 homolog, Flii, Fli1 Fliih
UniProt Protein Function:
FLI: May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration. Deletion of the FLII gene may be a cause of Smith-Magenis syndrome (SMS). It is a contiguous gene deletion syndrome involving developmental abnormalities and mental retardation. The spectrum of clinical findings includes short stature, brachydactyly, developmental delay, dysmorphic features, sleep disturbances, and behavioral problems.Protein type: Nuclear receptor co-regulator; Actin-bindingCellular Component: brush border; cell junction; cytoplasm; cytoskeleton; microtubule organizing center; nucleoplasm; nucleusMolecular Function: actin binding; protein bindingBiological Process: actin cytoskeleton organization and biogenesis; actin filament severing; multicellular organismal development; regulation of transcription, DNA-dependent; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein with gelsolin-like repeats and an N-terminal leucine-rich repeat domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. This protein may act as an actin-remodelling protein as well as a transcriptional coactivator. Homozygous knockout mice show embryonic lethality. This protein may act to regulate wound repair. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
