The FKBP52 Rabbit Monoclonal Antibody (CAB4356) is a cutting-edge tool for researchers studying FKBP52, a protein involved in regulating immune responses and cellular processes. This highly specific antibody, produced in rabbits, has been rigorously validated for use in Western blot applications and is known for its exceptional reactivity with human samples.FKBP52 is a key player in the immune system, with implications in various diseases including cancer, autoimmune disorders, and inflammatory conditions. The antibody binds specifically to FKBP52, allowing for the precise detection and analysis of this protein in different cell types.
This makes it an invaluable resource for investigations into immunology and cancer research.By targeting FKBP52, researchers can gain valuable insights into the mechanisms underlying immune regulation and disease pathogenesis. This antibody offers a reliable and accurate way to study FKBP52's role in health and disease, paving the way for the development of novel therapeutic strategies targeting this protein.
Product Name:
FKBP52/FKBP4 Rabbit Monoclonal Antibody
SKU:
CAB4356
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human FKBP4 (Q02790).
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.
Purification Method:
Affinity purification
Gene ID:
2288
Clone Number:
ARC0977
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FKBP52/FKBP4 Rabbit mAb (CAB4356) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
