The FKBP5 Polyclonal Antibody (CAB3863) is a valuable tool for research involving the FKBP5 protein, which plays a crucial role in regulating the stress response and impacting mood disorders such as depression and anxiety. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications.FKBP5, a member of the FK506-binding protein (FKBP) family, is known to interact with hormone receptors and modulate their activity, ultimately influencing stress hormone signaling pathways. Dysregulation of FKBP5 has been linked to various psychiatric disorders and is a promising target for therapeutic interventions.
With the ability to detect and analyze FKBP5 protein expression in different cell types, this antibody is ideal for studies in neuroscience, psychiatry, and endocrinology. By understanding the role of FKBP5 in stress response regulation, researchers can gain insights into the mechanisms underlying stress-related disorders and potentially develop novel treatment strategies. Order now to enhance your research on FKBP5 and its implications in mental health and stress-related conditions.
Product Name:
FKBP51/FKBP5 Rabbit Polyclonal Antibody
SKU:
CAB3863
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 308-457 of human FKBP51/FKBP5 (NP_001139247.1).
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2289
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FKBP51/FKBP5 Rabbit pAb (CAB3863) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
