FKBP52/FKBP4 Rabbit Polyclonal Antibody (CAB5643)
- SKU:
- CAB5643
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | FKBP52/FKBP4 Rabbit Polyclonal Antibody |
SKU: | CAB5643 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-459 of human FKBP52/FKBP52/FKBP4 (NP_002005.1). |
Sequence: | YLKP SYAF GSVG KEKF QIPP NAEL KYEL HLKS FEKA KESW EMNS EEKL EQST IVKE RGTV YFKE GKYK QALL QYKK IVSW LEYE SSFS NEEA QKAQ ALRL ASHL NLAM CHLK LQAF SAAI ESCN KALE LDSN NEKG LFRR GEAH LAVN DFEL ARAD FQKV LQLY PNNK AAKT QLAV CQQR IRRQ LARE KKLY ANMF ERLA EEEN KAKA EASS GDHP TDTE MKEE QKSN TAGS QSQV ETEA |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:100 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | HBI; p52; Hsp56; FKBP51; FKBP52; FKBP59; PPIase; FKBP52/FKBP4 |
Positive Sample: | HeLa,Jurkat,Mouse testis,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Mitochondrion, Nucleus, cytoskeleton, cytosol. |
Calculated MW: | 52kDa |
Observed MW: | 52kDa |
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.
Purification Method: | Affinity purification |
Gene ID: | 2288 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |