The FKBP4 Polyclonal Antibody (CAB5643) is a valuable tool for researchers studying FKBP4, a key protein involved in cell signaling and protein folding. This antibody, produced in rabbits, exhibits high specificity and sensitivity when used in Western blot applications with human samples. By targeting the FKBP4 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for investigations in molecular biology and drug development.FKBP4, also known as FK506-binding protein 4, plays a crucial role in modulating protein folding and stability, making it a potential therapeutic target for various diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions.
Understanding the function of FKBP4 is essential for developing targeted therapies that can manipulate protein interactions and cellular processes implicated in these diseases. By utilizing the FKBP4 Polyclonal Antibody, researchers can uncover new insights into the mechanisms underlying disease progression and potentially identify novel treatment strategies.
Product Name:
FKBP52/FKBP4 Rabbit Polyclonal Antibody
SKU:
CAB5643
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 220-459 of human FKBP52/FKBP52/FKBP4 (NP_002005.1).
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.
Purification Method:
Affinity purification
Gene ID:
2288
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using FKBP52/FKBP4 Rabbit pAb (CAB5643) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
