The FKBP3 Polyclonal Antibody (CAB6907) is a valuable tool for researchers studying FKBP3, a member of the immunophilin protein family involved in protein folding and trafficking. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.FKBP3 is known to play a role in various cellular processes, including immune response regulation and cell signaling. By targeting the FKBP3 protein, this antibody allows for the detection and analysis of FKBP3 expression in different cell types, making it an essential component in studies related to immunology and cancer research.
The FKBP3 Polyclonal Antibody can provide valuable insights into the function and regulation of FKBP3, contributing to the development of therapies targeting this protein in diseases such as cancer, autoimmune disorders, and inflammatory conditions. Researchers can utilize this antibody to advance their understanding of FKBP3's role in cellular pathways and its potential as a therapeutic target.
Product Name:
FKBP3 Rabbit Polyclonal Antibody
SKU:
CAB6907
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human FKBP3 (NP_002004.1).
WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
FKBP-3; FKBP25; PPIase; FKBP-25; FKBP3
Positive Sample:
HeLa,MCF-7,BT-474
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
25kDa
Observed MW:
30kDa
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
Purification Method:
Affinity purification
Gene ID:
2287
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using FKBP3 Rabbit pAb (CAB6907) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
