The FKBP1A Polyclonal Antibody (CAB1763) is a vital tool for researchers studying FKBP1A, a protein involved in immunoregulation and cell signaling pathways. This antibody, produced in rabbits, demonstrates high specificity and reactivity with human samples, making it ideal for Western blot applications. By binding to FKBP1A, the antibody enables precise detection and analysis of the protein in various cell types, facilitating investigations in immunology and cancer research.FKBP1A, also known as FK506-binding protein 1A, is a key player in modulating immune responses and cellular processes. Its involvement in protein folding and intracellular signaling pathways makes it an attractive target for studying diseases such as cancer, autoimmune disorders, and neurological conditions.
Understanding the function of FKBP1A is crucial for unraveling its role in disease pathogenesis and developing targeted therapeutic interventions.This FKBP1A Polyclonal Antibody provides researchers with a reliable tool for studying the expression and localization of FKBP1A in diverse experimental settings. With its high specificity and sensitivity, it enables precise and accurate analysis of FKBP1A levels, paving the way for advancements in basic and translational research in the fields of immunology and oncology.
Product Name:
FKBP12 Rabbit Polyclonal Antibody
SKU:
CAB1763
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2-108 of FKBP12 (NP_000792.1).
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.
Purification Method:
Affinity purification
Gene ID:
2280
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FKBP12 Rabbit pAb (CAB1763) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
