The FIZ1 Polyclonal Antibody (PAC061430) is a valuable tool for research involving FIZ1, a protein that plays a role in chromatin remodeling and gene expression regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the FIZ1 protein, this antibody enables accurate detection and analysis in various cell types, making it well-suited for studies in molecular biology and cancer research.
FIZ1 is known for its involvement in epigenetic regulation, specifically in the modification of histone proteins to control gene expression. Understanding the functions of FIZ1 is important for unraveling the molecular mechanisms underlying various diseases, including cancer and developmental disorders. Research on FIZ1 may lead to insights into potential therapeutic targets and strategies for managing these conditions.
Western Blot. Positive WB detected in: 293 whole cell lysate. All lanes: FIZ1 antibody at 4.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 52 kDa. Observed band size: 52 kDa.
IHC image of PACO61430 diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).
Synonyms:
Flt3-interacting zinc finger protein 1, Zinc finger protein 798, FIZ1, ZNF798
UniProt Protein Function:
FIZ1: May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation.Protein type: C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 19q13.42Cellular Component: cytoplasm; nucleusMolecular Function: receptor tyrosine kinase binding
UniProt Protein Details:
NCBI Summary:
This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008]
