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FITC Anti-Mouse CD272 Antibody [PK18.6] (AGEL3185)

SKU:
AGEL3185
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG1, k
Clone:
PK18.6
Conjugation:
FITC
€169 - €389
Frequently bought together:

Description

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FITC Anti-Mouse CD272 Antibody [PK18.6]

The FITC Anti-Mouse CD272 Antibody (PK18-6) is a specialized research tool offered by Assay Genie for investigating mouse CD272, a cell surface molecule involved in immune regulation. This antibody is designed to target CD272 specifically, allowing for precise detection and analysis in various experimental settings.CD272, also known as B and T Lymphocyte Attenuator (BTLA), plays a crucial role in modulating immune responses by inhibiting the activation of T cells and suppressing immune reactions. This makes CD272 an interesting target for studies related to immunology and immunotherapy. The FITC Anti-Mouse CD272 Antibody is highly reactive with mouse samples and is validated for use in fluorescence-based applications, such as flow cytometry and immunofluorescence microscopy.

By accurately detecting and measuring CD272 expression, researchers can gain insights into the function of this immune checkpoint molecule and its potential implications in various disease contexts, including cancer, autoimmune disorders, and infectious diseases. This antibody provides a valuable tool for advancing our understanding of immune regulation and developing innovative therapeutic strategies targeting CD272 pathways.

Product Title:FITC Anti-Mouse CD272 Antibody [PK18.6]
SKU:AGEL3185
Size:50 Tests, 100 Tests, 200 Tests
Clone No:PK18.6
Synonyms:B- and T-lymphocyte attenuator;Btla;B- and T-lymphocyte-associated protein;CD272;Btla;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:FITC Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q7TSA3
Gene ID:208154
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

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