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FITC Anti-Mouse CD200 Antibody [OX-90] (AGEL3386)

SKU:
AGEL3386
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, k
Clone:
OX-90
Conjugation:
FITC
€159 - €369
Frequently bought together:

Description

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FITC Anti-Mouse CD200 Antibody [OX-90]

The FITC Anti-Mouse CD200 Antibody (OX-90) (AGEL3386) is a highly specific antibody designed for research involving CD200, a cell surface glycoprotein known for its immunomodulatory properties. This antibody, optimized for fluorescence microscopy and flow cytometry applications, is raised in mice and exhibits high affinity and specificity for mouse CD200.CD200, also referred to as OX-2, is a key molecule involved in immune regulation, with roles in suppressing inflammation and modulating immune responses. Its expression on various cell types, including lymphocytes and neurons, makes it a valuable target for investigating immune function in both normal and pathological conditions.

This FITC-conjugated antibody allows for precise detection and visualization of CD200 expression in mouse samples, providing researchers with a powerful tool for studying the role of CD200 in immunology, neurobiology, and cancer research. By understanding the functions and mechanisms of CD200, researchers can gain insights into immune tolerance, neuroinflammation, and potential therapeutic targets for immune-related diseases and disorders.

Product Title:FITC Anti-Mouse CD200 Antibody [OX-90]
SKU:AGEL3386
Size:25µg, 100µg
Clone No:OX-90
Synonyms:OX-2 membrane glycoprotein;OX-2; MRC;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:FITC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:O54901
Gene ID:4345
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD200 (OX-2 antigen) is a type-1 membrane glycoprotein containing two extracellular Ig-like domains. CD200 a highly conserved type I membrane glycoprotein that is expressed on a variety of cell types including thymocytes, some T cells, endothelial and follicular dendritc cells, B cells, and brain tissue (neurons); but not on NK cells, granulocytes, monocytes, or macrophages. CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues. CD200 is the ligand for CD200 receptor (CD200R). The CD200 Receptor is restricted to myeloid cells, and it is believed that its engagement with CD200 results in inhibition and/or downregulation of myeloid cell activity. Blocking of CD200/CD200R interactions decreases myeloid cell inhibitory thresholds which results in enhanced immune activation.

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