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FITC Anti-Mouse CD162 Antibody [4RA10] (AGEL3194)

SKU:
AGEL3194
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG1, k
Clone:
4RA10
Conjugation:
FITC
€139 - €259
Frequently bought together:

Description

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FITC Anti-Mouse CD162 Antibody [4RA10]

The FITC Anti-Mouse CD162 Antibody (4RA10) offered by Assay Genie is a high-quality tool for researchers studying CD162, a cell surface molecule involved in immune cell trafficking and inflammation regulation in mice. This antibody, conjugated with FITC for convenient fluorescence detection, is specifically designed for flow cytometry applications, enabling precise analysis of CD162 expression in various mouse cell types.CD162, also known as P-selectin glycoprotein ligand 1 (PSGL-1), plays a key role in mediating leukocyte rolling and adhesion to vascular endothelium during immune responses. Understanding the function and regulation of CD162 is essential for unraveling mechanisms of immune cell recruitment and tissue inflammation in various disease contexts.

The FITC Anti-Mouse CD162 Antibody (4RA10) from Assay Genie provides reliable and sensitive detection of CD162, facilitating detailed investigations into immune cell behavior and response dynamics in mouse models.This antibody is ideal for immunology studies, inflammation research, and investigations into immune cell trafficking mechanisms. Its specificity and performance in flow cytometry make it a valuable tool for unraveling the intricacies of CD162 function and regulation, shedding light on new therapeutic opportunities for conditions involving immune cell recruitment and inflammation.

Product Title:FITC Anti-Mouse CD162 Antibody [4RA10]
SKU:AGEL3194
Size:25µg, 100µg
Clone No:4RA10
Synonyms:P-selectin glycoprotein ligand 1;Selplg;PSGL-1;Selectin P ligand;CD162;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:FITC Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q62170
Gene ID:20345
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be specifically sialylated, fucosylated, and sulfated to bind P-selectin. There is also evidence that other ligands for PSGL-1 and CD62P may exist. 4RA10 mAb is reported to block the binding of mouse leukocytes to CD62P and CD62L.

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