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FITC Anti-Human CD22 Antibody [BU59]

SKU:
AGEL2817
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG1, κ
Clone:
BU59
Conjugation:
FITC
€169 - €539
Frequently bought together:

Description

FITC Anti-Human CD22 Antibody [BU59]

The FITC Anti-Human CD22 Antibody (BU59) is a specialized research tool available at Assay Genie for studying CD22, a cell surface molecule predominantly expressed in B cells. This antibody is meticulously engineered for its high specificity and sensitivity towards human samples, allowing for precise detection and analysis in various experimental settings.CD22, a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family, plays a vital role in B cell receptor signaling and B cell development. It is involved in modulating B cell activation and tolerance, making it a key target for investigations in immunology, particularly in the context of autoimmune diseases and B cell-related malignancies.

The FITC conjugation of this antibody provides a fluorescent marker that enables visualization and tracking of CD22 expression in flow cytometry and immunofluorescence assays. With its reliable performance and compatibility with a range of techniques, the FITC Anti-Human CD22 Antibody (BU59) is an invaluable tool for researchers exploring the functional roles of CD22 in both normal and pathological immune responses.

Product Name:FITC Anti-Human CD22 Antibody [BU59]
Product Code:AGEL2817
Clone No:BU59
Synonyms:B-cell receptor CD22,Cd22,B-lymphocyte cell adhesion molecule,BL-CAM,Sialic acid-binding Ig-like lectin 2,Siglec-2,T-cell surface antigen Leu-14,CD22,Lyb-8, Siglec2
Reactivity:Human
Host Species:Mouse
Applications:FCM
Isotype:Mouse IgG1, κ
Isotype Control:FITC Mouse IgG1, κ Isotype Control [MOPC-21] (AGEL2549)
Conjugation:FITC
Form:Liquid
Fluorescent Label:FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter).
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Swissprot:P20273
Stability & Storage:Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Shipping:Biological ice pack at 4°C

CD22 is a 130 kD type I transmembrane glycoprotein also known as Siglec-2 and BL-CAM. It is a member of the immunoglobulin superfamily (sialoadhesion subgroup). CD22 is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B and activated B cells, but not on plasma cells. CD22 is present in the B cell receptor complex and associates with SHP-1, Syk, Lck, Lyn, and phospholipase Cγ1. A primary function of CD22 is thought to be in limiting antigen receptor signaling by modulating B cell activation threshold. CD22 has been shown to bind to CD45RO and CD75, although the natural ligands for this molecule remain controversial.

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