FIP1L1 Rabbit Polyclonal Antibody (CAB7138)
- SKU:
- CAB7138
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | FIP1L1 Rabbit Polyclonal Antibody |
SKU: | CAB7138 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human FIP1L1 (NP_001128409.1). |
Sequence: | MSAG EVER LVSE LSGG TGGD EEEE WLYG DENE VERP EEEN ASAN PPSG IEDE TAEN GVPK PKVT ETED DSDS DSDD DEDD VHVT IGDI KTGA PQYG SYGT APVN LNIK TGGR VYGT TGTK VKGV DLDA PGSI NGVP LLEV DLDS FEDK PWRK PGAD LSDY FNYG FNED TWKA YCEK QKRI RMGL EVIP VTST TNKI TAED CTME VTPG AEIQ DGRF NLFK VQQG RTGN SEKE TALP STKA EFTS PPSL FKTG LPPS RNST SSQS QTST ASRK ANSS VGKW QDRY GRAE SPDL RRLP GAID |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:100 |
Synonyms: | Rhe; FIP1; hFip1; FIP1L1 |
Positive Sample: | Jurkat,293F,Mouse thymus,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 67kDa |
Observed MW: | 75kDa |
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method: | Affinity purification |
Gene ID: | 81608 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |