The FILIP1 Antibody (PAC048674) is a vital tool for researchers studying FILIP1, a protein that plays a key role in regulating cell proliferation and migration. This polyclonal antibody, produced in rabbits, demonstrates high specificity and sensitivity in detecting FILIP1 in human samples, making it ideal for use in Western blot applications.FILIP1, also known as FHL-1C, is involved in cell adhesion and motility processes, making it an essential protein to study in the context of cancer metastasis and tumor progression. Understanding the function of FILIP1 can provide valuable insights into the mechanisms underlying these processes and may lead to the development of targeted therapies for cancer treatment.
By using the FILIP1 Antibody, researchers can accurately detect and analyze FILIP1 expression in various cell types, enabling further exploration of its role in cancer biology. This antibody is a valuable tool for studies aiming to uncover the molecular mechanisms driving cancer progression and identify potential therapeutic targets for intervention.
Immunohistochemistry of paraffin-embedded human heart tissue using PACO48674 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO48674 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A.
Synonyms:
Filamin-A-interacting protein 1 (FILIP), FILIP1, KIAA1275
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016]
