The Filamin B Polyclonal Antibody (CAB2481) is a valuable tool for researchers studying Filamin B, a cytoskeletal protein that plays a crucial role in cell motility and structure. This antibody, generated in rabbits, exhibits high specificity and sensitivity for Filamin B in human samples, making it an excellent choice for Western blot applications. By targeting the Filamin B protein, this antibody allows for the detection and analysis of Filamin B expression in various cell types, making it an essential tool for investigations in cell biology, cancer research, and developmental biology.
Filamin B is a key regulator of actin dynamics and cellular signaling pathways, contributing to processes like cell adhesion, migration, and shape formation. Dysregulation of Filamin B has been implicated in various diseases, including developmental disorders, cancer, and muscular dystrophy. Through research using the Filamin B Polyclonal Antibody, scientists can deepen their understanding of the mechanisms by which Filamin B influences cellular function and disease progression, ultimately paving the way for potential therapeutic interventions targeting Filamin B-related conditions.
Product Name:
FLNB Rabbit Polyclonal Antibody
SKU:
CAB2481
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1686-1785 of human FLNB (NP_001157789.1).
Cytoplasm, Z line, cell cortex, cytoskeleton, myofibril, sarcomere.
Calculated MW:
278kDa
Observed MW:
298kDa
This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
2317
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using FLNB Rabbit pAb (CAB2481) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (AbGn00020)._Exposure time: 10s.
