The Filamin A Rabbit Monoclonal Antibody (CAB3738) is a cutting-edge tool for researchers studying Filamin A, a key protein involved in cell structure and signaling pathways. This high-quality antibody, developed in rabbits, is specifically designed to target Filamin A in human samples and is validated for use in Western blot applications. By binding to Filamin A, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential tool for studies in cell biology, signal transduction, and disease mechanisms.Filamin A is a crucial protein that plays a significant role in cell adhesion, migration, and cytoskeletal organization.
Dysregulation of Filamin A has been linked to various diseases, including cancer, neurological disorders, and cardiovascular conditions. Understanding the function and regulation of Filamin A is essential for unraveling its impact on cell behavior and disease progression. Researchers can leverage the Filamin A Rabbit Monoclonal Antibody to uncover new insights into Filamin A-related mechanisms and develop potential therapeutic strategies for diseases associated with Filamin A dysfunction.
Product Name:
Filamin A Rabbit Monoclonal Antibody
SKU:
CAB3738
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 2548-2647 of human Filamin A (P21333).
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2316
Clone Number:
ARC0242
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Filamin A Rabbit mAb (CAB3738) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
