Filamin A Rabbit Monoclonal Antibody (CAB3738)
- SKU:
- CAB3738
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | Filamin A Rabbit Monoclonal Antibody |
SKU: | CAB3738 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 2548-2647 of human Filamin A (P21333). |
Sequence: | GAPG PGPA DASK VVAK GLGL SKAY VGQK SSFT VDCS KAGN NMLL VGVH GPRT PCEE ILVK HVGS RLYS VSYL LKDK GEYT LVVK WGDE HIPG SPYR VVVP |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:100 - 1:500 |
Synonyms: | FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FGS2; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280; Filamin A |
Positive Sample: | HeLa,U-937,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, cell cortex, cytoskeleton, Perikaryon, Cell projection, growth cone. |
Calculated MW: | 281kDa |
Observed MW: | 280kDa |
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 2316 |
Clone Number: | ARC0242 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |