The Filamin A Polyclonal Antibody (CAB7896) is a valuable tool for researchers studying Filamin A, a protein involved in cell structure and signaling pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding to Filamin A, this antibody enables the detection and analysis of the protein in a variety of cell types, making it an essential component for studies in cell biology and cancer research.Filamin A is a crucial protein in maintaining cellular structure and function, playing key roles in processes such as cell migration, adhesion, and signaling.
Dysregulation of Filamin A has been implicated in various diseases, including cancer, cardiovascular disorders, and neurodevelopmental conditions. Therefore, investigating the role of Filamin A in these contexts is essential for understanding disease mechanisms and developing targeted therapies.By using the Filamin A Polyclonal Antibody (CAB7896) in your research, you can gain valuable insights into the function and regulation of Filamin A, ultimately contributing to advancements in the fields of cell biology, cancer research, and beyond.
Product Name:
Filamin A Rabbit Polyclonal Antibody
SKU:
CAB7896
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 2548-2647 of human Filamin A (NP_001104026.1).
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2316
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Filamin A Rabbit pAb (CAB7896) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
