The FIGN Polyclonal Antibody (PACO47414) is a vital tool for researchers studying FIGN, a protein involved in immune regulation and cell signaling pathways. This antibody, produced through immunization of rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting.FIGN, also known as immune protein FIGN, plays a crucial role in immune response modulation and has been implicated in various diseases, including cancer and autoimmune disorders. By targeting FIGN with this polyclonal antibody, researchers can detect and analyze its expression in different cell types, allowing for further insight into its function and potential therapeutic applications.
With its ability to bind specifically to FIGN, the PACO47414 antibody is an essential tool for investigators in the fields of immunology and cancer research. Its versatility and reliability make it an ideal choice for studies aiming to unravel the role of FIGN in immune regulation and disease pathogenesis.
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO47414 at dilution of 1:100.
Western Blot. Positive WB detected in: HepG2 whole cell lysate, Mouse brain tissue. All lanes: FIGN antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 83 kDa. Observed band size: 83, 38 kDa.
Immunofluorescent analysis of Hela cells using PACO47414 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.
Synonyms:
Fidgetin, FIGN
UniProt Protein Function:
FIGN: Belongs to the AAA ATPase family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 2q24.3Cellular Component: nuclear matrix; nucleusMolecular Function: microtubule-severing ATPase activityBiological Process: cytoplasmic microtubule organization and biogenesis
