FIGN Antibody (PACO47414)
- SKU:
- PACO47414
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | FIGN Antibody (PACO47414) |
| Antibody SKU: | PACO47414 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Fidgetin protein (132-371AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO47414 at dilution of 1:100. |
 | Western Blot. Positive WB detected in: HepG2 whole cell lysate, Mouse brain tissue. All lanes: FIGN antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 83 kDa. Observed band size: 83, 38 kDa. |
 | Immunofluorescent analysis of Hela cells using PACO47414 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. |
| Synonyms: | Fidgetin, FIGN |
| UniProt Protein Function: | FIGN: Belongs to the AAA ATPase family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 2q24.3Cellular Component: nuclear matrix; nucleusMolecular Function: microtubule-severing ATPase activityBiological Process: cytoplasmic microtubule organization and biogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q5HY92 |
| NCBI GenInfo Identifier: | 115502199 |
| NCBI Gene ID: | 55137 |
| NCBI Accession: | Q5HY92.2 |
| UniProt Secondary Accession: | Q5HY92,Q9H6M5, Q9NVZ9, B3KWM0 |
| UniProt Related Accession: | Q5HY92 |
| Molecular Weight: | 82,146 Da |
| NCBI Full Name: | Fidgetin |
| NCBI Synonym Full Names: | fidgetin, microtubule severing factor |
| NCBI Official Symbol: | FIGNÂ Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | fidgetin |
| UniProt Protein Name: | Fidgetin |
| UniProt Synonym Protein Names: | |
| Protein Family: | Fidgetin |
| UniProt Gene Name: | FIGNÂ Â |
| UniProt Entry Name: | FIGN_HUMAN |