The Fig4 Polyclonal Antibody (CAB15372) is a versatile tool for researchers studying the Fig4 protein, a key player in cellular signaling pathways and vesicle trafficking. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human Fig4 protein, making it an ideal choice for Western blot applications.Fig4, a phosphoinositide phosphatase, is involved in the regulation of membrane trafficking and has been implicated in various physiological processes, such as autophagy and lysosomal function.
Dysregulation of Fig4 has been linked to neurodegenerative diseases and lysosomal storage disorders, highlighting its importance in cellular homeostasis.By utilizing the Fig4 Polyclonal Antibody, researchers can explore the role of Fig4 in different cellular contexts and gain valuable insights into its function. This antibody is a valuable tool for studying cellular signaling pathways, membrane dynamics, and vesicle trafficking, making it indispensable for research in cell biology and neurobiology.
Product Name:
FIG4 Rabbit Polyclonal Antibody
SKU:
CAB15372
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 608-907 of human FIG4 (NP_055660.1).
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.
Purification Method:
Affinity purification
Gene ID:
9896
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FIG4 Rabbit pAb (CAB15372) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
