FIG4 Rabbit Polyclonal Antibody (CAB15372)
- SKU:
- CAB15372
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
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Description
Product Name: | FIG4 Rabbit Polyclonal Antibody |
SKU: | CAB15372 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 608-907 of human FIG4 (NP_055660.1). |
Sequence: | WELP TDFY LHHK NTMR LLPT RRSY TYWW TPEV IKHL PLPY DEVI CAVN LKKL IVKK FHKY EEEI DIHN EFFR PYEL SSFD DTFC LAMT SSAR DFMP KTVG IDPS PFTV RKPD ETGK SVLG NKSN REEA VLQR KTAA SAPP PPSE EAVS SSSE DDSG TDRE EEGS VSQR STPV KMTD AGDS AKVT ENVV QPMK ELYG INLS DGLS EEDF SIYS RFVQ LGQS QHKQ DKNS QQPC SRCS DGVI KLTP ISAF SQDN IYEV QPPR VDRK STEI FQAH IQAS QGIM QPLG KEDS SMYR EYIR NRYL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:2000 |
Synonyms: | BOP; YVS; BTOP; SAC3; ALS11; CMT4J; KIAA0274; dJ249I4.1; FIG4 |
Positive Sample: | U-251MG,HT-29,Jukat,HeLa,Mouse liver,Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Endosome membrane. |
Calculated MW: | 104kDa |
Observed MW: | 104kDa |
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.
Purification Method: | Affinity purification |
Gene ID: | 9896 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |