The Fibulin-5 Polyclonal Antibody (CAB9961) is a valuable tool for researchers studying the Fibulin-5 protein, which is involved in important biological processes such as tissue development and homeostasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Fibulin-5 is a crucial component of the extracellular matrix, where it plays a role in regulating cell adhesion, migration, and signaling. Dysregulation of Fibulin-5 has been implicated in various diseases, including cardiovascular disorders, cancer, and connective tissue disorders.
Therefore, studying the expression and function of Fibulin-5 using this antibody can provide valuable insights into the mechanisms underlying these conditions.By specifically binding to Fibulin-5, this antibody enables accurate detection and analysis of the protein in different cell types and tissues. Its versatility and reliability make it an ideal choice for research in fields such as cell biology, tissue engineering, and disease pathology. Overall, the Fibulin-5 Polyclonal Antibody is a valuable tool for advancing our understanding of the roles played by Fibulin-5 in health and disease.
Product Name:
FBLN5 Rabbit Polyclonal Antibody
SKU:
CAB9961
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 199-448 of human FBLN5 (NP_006320.2).
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
Purification Method:
Affinity purification
Gene ID:
10516
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FBLN5 antibody (CAB9961) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
