Anti-FIBP Antibody (CAB13572)
- SKU:
- CAB13572
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Anti-FIBP Antibody (CAB13572)
The FIBP Polyclonal Antibody (CAB13572) is a valuable tool for researchers studying FIBP, a protein involved in various cellular processes including cell proliferation and differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.FIBP, also known as FGF2 mRNA-binding protein, plays a critical role in regulating the expression of fibroblast growth factor 2 (FGF2), a potent angiogenic factor involved in tumor growth and metastasis.
By targeting FIBP, researchers can investigate the role of FGF2 and its downstream signaling pathways in cancer progression.The FIBP Polyclonal Antibody enables the detection and analysis of FIBP protein in different cell types, providing valuable insights into its functions in cancer biology. This antibody is a valuable tool for studies in oncology and may contribute to the development of targeted therapies for FGF2-dependent tumors.
| Antibody Name: | Anti-FIBP Antibody |
| Antibody SKU: | CAB13572 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-364 of human FIBP (NP_004205.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | BxPC-3, Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-364 of human FIBP (NP_004205.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTSE LDIF VGNT TLID EDVY RLWL DGYS VTDA VALR VRSG ILEQ TGAT AAVL QSDT MDHY RTFH MLER LLHA PPKL LHQL IFQI PPSR QALL IERY YAFD EAFV REVL GKKL SKGT KKDL DDIS TKTG ITLK SCRR QFDN FKRV FKVV EEMR GSLV DNIQ QHFL LSDR LARD YAAI VFFA NNRF ETGK KKLQ YLSF GDFA FCAE LMIQ NWTL GAVD SQMD DMDM DLDK EFLQ DLKE LKVL VADK DLLD LHKS LVCT ALRG KLGV FSEM EANF KNLS RGLV NVAA KLTH NKDV RDLF VDLV EKFV EPCR SDHW PLSD VRFF LNQY SASV HSLD GFRH QALW DRYM GTLR GCLL RLYH D |
| Gene ID: | 9158 |
| Uniprot: | O43427 |
| Cellular Location: | Endomembrane system, Nucleus, Peripheral membrane protein |
| Calculated MW: | 41kDa |
| Observed MW: | 42kDa |
| Synonyms: | FIBP, FGFIBP, FIBP-1, TROFAS |
| Background: | Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | FIBP: May be involved in mitogenic function of FGF1. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q13.1 Cellular Component: nucleoplasm; membrane; mitochondrion; endomembrane system; nucleus Molecular Function:fibroblast growth factor binding Biological Process: fibroblast growth factor receptor signaling pathway |
| NCBI Summary: | Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43427 |
| NCBI GenInfo Identifier: | 13431517 |
| NCBI Gene ID: | 9158 |
| NCBI Accession: | O43427.3 |
| UniProt Secondary Accession: | O43427,Q27Q85, Q6IBQ3, Q9HD65, A8K0J7, |
| UniProt Related Accession: | O43427 |
| Molecular Weight: | 364 |
| NCBI Full Name: | Acidic fibroblast growth factor intracellular-binding protein |
| NCBI Synonym Full Names: | fibroblast growth factor (acidic) intracellular binding protein |
| NCBI Official Symbol: | FIBPÂ Â |
| NCBI Official Synonym Symbols: | FGFIBP; FIBP-1Â Â |
| NCBI Protein Information: | acidic fibroblast growth factor intracellular-binding protein; aFGF intracellular-binding protein; FGF-1 intracellular-binding protein |
| UniProt Protein Name: | Acidic fibroblast growth factor intracellular-binding protein |
| UniProt Synonym Protein Names: | FGF-1 intracellular-binding protein |
| Protein Family: | Acidic fibroblast growth factor intracellular-binding protein |
| UniProt Gene Name: | FIBPÂ Â |
| UniProt Entry Name: | FIBP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FIBP antibody (CAB13572) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse heart using FIBP antibody (CAB13572) at dilution of 1:100 (40x lens). |
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