The FHL3 Polyclonal Antibody (CAB8679) is a valuable tool for researchers studying FHL3, a member of the four-and-a-half LIM domain protein family known to be involved in signal transduction and cell differentiation. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it an ideal choice for Western blot applications. By specifically binding to the FHL3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it particularly useful in immunology and cancer research.FHL3, also known as four and a half LIM domains protein 3, is known to play a crucial role in regulating gene expression and cell signaling pathways.
Its involvement in these processes suggests potential implications in various diseases, including cancer and developmental disorders. By studying the function of FHL3, researchers may uncover new insights into the underlying mechanisms of these conditions and potentially identify novel therapeutic targets.Overall, the FHL3 Polyclonal Antibody (CAB8679) offers researchers a reliable tool for investigating the role of FHL3 in cellular processes and disease pathways, ultimately contributing to advancements in biomedical research and potential clinical applications.
Product Name:
FHL3 Rabbit Polyclonal Antibody
SKU:
CAB8679
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human FHL3 (NP_004459.2).
The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2275
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FHL3 antibody (CAB8679) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
