The FHIT Rabbit Monoclonal Antibody (CAB9072) is a specialized tool for studying the FHIT protein, a tumor suppressor implicated in various cancers. This antibody, developed in rabbits, shows high specificity and sensitivity towards FHIT in human samples, making it a reliable choice for Western blot applications. By binding to the FHIT protein, this antibody enables precise detection and analysis in different cell types, offering valuable insights for cancer research and drug development efforts.
FHIT, or fragile histidine triad protein, plays a crucial role in maintaining genomic stability and preventing the formation of tumors. Its loss or inactivation is commonly observed in a wide range of malignancies, making it a promising target for diagnostic and therapeutic interventions. By studying the functions of FHIT using this antibody, researchers can uncover new strategies for detecting and treating cancer, ultimately improving patient outcomes.
Product Name:
FHIT Rabbit Monoclonal Antibody
SKU:
CAB9072
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FHIT (P49789).
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage.
Purification Method:
Affinity purification
Gene ID:
2272
Clone Number:
ARC1401
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using FHIT Rabbit mAb (CAB9072) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
