This FH Polyclonal Antibody (CAB5688) is specifically designed for research involving the FH protein, a key regulator of the alternative pathway of the complement system. The antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the FH protein, this antibody enables efficient detection and analysis in various cell types, making it an invaluable tool for studies in immunology and complement-mediated diseases.The FH protein plays a crucial role in preventing excessive activation of the complement system and protecting host cells from damage. Dysregulation of FH function has been implicated in various diseases, including autoimmune disorders, inflammatory conditions, and certain kidney diseases.
Therefore, understanding the function and regulation of FH is essential for developing targeted therapies and diagnostic tools for these conditions.By using the FH Polyclonal Antibody (CAB5688), researchers can gain valuable insights into the mechanisms underlying complement system activation and regulation, ultimately advancing our knowledge of immune responses and disease pathogenesis. Whether studying basic immunology or seeking potential therapeutic targets, this antibody provides a reliable and effective tool for your research needs.
Product Name:
FH Rabbit Polyclonal Antibody
SKU:
CAB5688
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 45-510 of human FH (NP_000134.2).
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
Purification Method:
Affinity purification
Gene ID:
2271
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using FH antibody (CAB5688) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
