The FGR Polyclonal Antibody (CAB2075) is a valuable tool for researchers studying the FGR protein, a member of the Src family of non-receptor tyrosine kinases. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting FGR in human samples, making it an essential component in Western blot applications. By specifically targeting the FGR protein, this antibody enables precise detection and analysis in a variety of cell types, making it suitable for investigations in immunology, cancer research, and beyond.FGR is a key player in cellular signaling pathways, particularly those involved in regulating cell growth, differentiation, and survival. Its role in oncogenesis and immune responses has garnered significant interest in the scientific community, as dysregulation of FGR has been implicated in various disease states, including cancer and inflammatory disorders.
By elucidating the functions of FGR, researchers can gain valuable insights into potential therapeutic targets and treatment strategies for these conditions.In conclusion, the FGR Polyclonal Antibody (CAB2075) offers researchers a reliable tool for studying the intricate functions of the FGR protein in diverse biological contexts. Its high specificity, sensitivity, and versatility make it an indispensable asset for advancing our understanding of cellular signaling pathways and identifying novel therapeutic interventions for diseases associated with FGR dysregulation.
Product Name:
FGR Rabbit Polyclonal Antibody
SKU:
CAB2075
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FGR (NP_005239.1).
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Purification Method:
Affinity purification
Gene ID:
2268
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FGR antibody (CAB2075) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
