FGR Rabbit Polyclonal Antibody (CAB2075)
- SKU:
- CAB2075
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | FGR Rabbit Polyclonal Antibody |
SKU: | CAB2075 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FGR (NP_005239.1). |
Sequence: | MGCV FCKK LEPV ATAK EDAG LEGD FRSY GAAD HYGP DPTK ARPA SSFA HIPN YSNF SSQA INPG FLDS GTIR GVSG IGVT LFIA LYDY EART EDDL TFTK |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr; FGR |
Positive Sample: | HL-60,U-937,Raji |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Lipid-anchor, Mitochondrion inner membrane, Mitochondrion intermembrane space, Peripheral membrane protein, cytoskeleton, cytosol, ruffle membrane. |
Calculated MW: | 59kDa |
Observed MW: | 53kDa |
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Purification Method: | Affinity purification |
Gene ID: | 2268 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |