The FGFR-Like 1 (FGFRL1) Monoclonal Antibody (PAC022744) is a valuable tool for researchers studying the FGFRL1 protein, which is a member of the fibroblast growth factor receptor (FGFR) family. This antibody, produced using cutting-edge technology, specifically recognizes and binds to FGFRL1 in human samples, making it ideal for various research applications.FGFRL1 is known to play a role in various cellular processes, including cell proliferation, differentiation, and migration, making it a key player in development and disease progression. By targeting FGFRL1 with this monoclonal antibody, researchers can gain valuable insights into its function and regulation in different cell types, particularly in the context of cancer and developmental biology studies.
With its high specificity and sensitivity, the FGFRL1 Monoclonal Antibody (PAC022744) is a reliable tool for investigating the role of FGFRL1 in various biological processes. Whether studying signaling pathways or protein interactions, this antibody offers researchers a versatile option for their research needs in molecular and cell biology.
Antibody Name:
FGFRL1 Antibody (PACO22744)
Antibody SKU:
PACO22744
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from Internal of human FGFRL1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Background:
Has a negative effect on cell proliferation By similarity.
FGFRL1: Has a negative effect on cell proliferation.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 4p16Cellular Component: Golgi apparatus; plasma membrane; transport vesicleMolecular Function: fibroblast growth factor receptor activity; heparin bindingBiological Process: fibroblast growth factor receptor signaling pathway; protein heterooligomerization; protein homooligomerizationDisease: Wolf-hirschhorn Syndrome
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
